A study published by MDPI recently (07/01/24) looked at the relationship between Herpesviruses and SARS0CoV-2. The human oral cavity contains a diverse microbial community, including viruses like herpesviruses and SARS-CoV-2, that influence oral and systemic health. Herpesviruses and SARS-CoV-2 have been implicated in oral diseases.
Common herpesviruses in the oral cavity include HSV-1, VZV, EBV, HCMV, and HHV-8. After primary infection, herpesviruses establish lifelong latent infections that may reactivate due to triggers like immunosuppression.
Both herpesviruses and SARS-CoV-2 are associated with periodontal disease, peri-implantitis, and endodontic infections. They contribute to immune dysregulation and tissue destruction in these oral inflammatory conditions.
The immunosuppression of COVID-19 may reactivate opportunistic oral infections like herpesviruses. Conversely, herpesvirus infections may also exacerbate COVID-19 severity. Further research is needed on their bidirectional relationship.
Given the links between systemic viral infections and oral disease, examining the potential associations between COVID-19 and oral manifestations is important. This review summarizes the involvement of trophic oral viruses – herpesviruses and SARS-CoV-2 – in oral inflammatory diseases.
The full study can be read here.