Nature recently published a study (19/01/24) looking at the effects on the brain of mild Covid-19 infections. Multiple studies have reported neurological manifestations of COVID-19, including cognitive dysfunction, fatigue, anxiety and depression. However, there is limited understanding of the nature and duration of these post-infectious symptoms, especially in mild outpatients.
The mechanisms underlying neurological symptoms remain unclear. Neuroimaging studies have found conflicting results regarding structural and functional brain changes after COVID-19. Most studies focused on hospitalized patients or did not use standard long COVID definitions.
This study evaluated non-hospitalized patients with confirmed COVID-19 after recovery, using CDC criteria for long COVID. Individuals with anxiety/depression were excluded. Clinical symptoms, cognition, fatigue, white matter integrity, and default mode network connectivity were examined.
The goal was to provide insights into neurological and cognitive sequalae of mild COVID-19 using consistent long COVID definitions in outpatients without confounding psychiatric conditions.
Understanding the impact of mild SARS-CoV-2 infection on brain structure and function will provide a foundation for uncovering mechanisms underlying diverse neuropsychiatric manifestations of long COVID.
You can read the full article here.